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Simon Luthi
Former Fortune 100 Executive at JPMorgan Chase and American Express; Bestselling Author of "Becoming the Rocket Shaman"; Creator of Transmutation Design™
Simon Luthi is a former Fortune 100 executive (Chief Strategy Officer at JPMorgan Chase, Head of Product at American Express) who helped scale Chase Travel from $2B to $10B. After a cancer diagnosis, he created Transmutation Design™, helping executives upgrade their human operating system for the AI era.
Bio
Simon Luthi is a former Fortune 100 executive who served as Chief Strategy Officer at JPMorgan Chase and Head of Product at American Express. Today he is a bestselling and award-winning author, keynote speaker, and creator of Transmutation Design™. After helping scale Chase Travel from $2 billion to $10 billion, a cancer diagnosis forced him to confront a truth most leaders ignore: in the AI era, leadership failure is often a biology problem, not a strategy problem.
Today, Simon helps executives stay healthy, sharp, and sovereign in a post-AI world by teaching leaders how to upgrade their human operating system. His work blends neuroscience, leadership, and personal transformation to help individuals and organizations perform at a higher level in an increasingly complex world.
Simon is the author of Becoming the Rocket Shaman, a #1 Amazon New Release and winner of Best Personal Transformation Book of 2025. He is a global keynote speaker on neuroscience and leadership in the post-AI era and has been featured on CBS, FOX, NBC, and more than 100 media outlets.
Keynotes
Featured Keynote
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2026: The Year Humanity Upgrades Its Operating System
How to Stay Healthy, Sharp, and Sovereign in a Post-AI Epoch
Every event planner building their 2026 agenda is asking the same question: what does leadership look like when AI is smarter than your executives?This keynote answers that question and proves it live on stage.
Simon makes the case that the leaders who fail in the AI era will not fail because they lacked intelligence, strategy, or tools. They will fail because their nervous systems are stuck in chronic survival mode, making high-stakes decisions while their bodies fight invisible tigers.
Using a continuous glucose monitor demonstration, Simon shows audiences in real time what stress does to the body. Glucose spikes from a phone call, not a plate of food. Then he shows what happens when a leader learns to regulate. The line flattens. Decision-making sharpens. Presence transforms.
Part science demonstration. Part phoenix story. Part executive wake-up call. Your body cannot tell the difference between a tiger and a Tuesday. This keynote proves it.
What Audiences Walk Away With:
- Understanding of the invisible stress cascade destroying executive performance
- The neuroscience behind why AI-era leadership requires nervous system regulation
- Practical techniques to interrupt fight-or-flight before critical decisions
- A new framework for measuring leadership readiness through biomarkers
Topics
- Artificial Intelligence Trending
- Future of Work
- Health & Wellness Trending
- Leadership Trending
- Peak Performance Trending
- Resilience Trending
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